Is a Catalyst Always Needed? The Case of the Knoevenagel Reaction with Malononitrile

Abstract The aim of this Perspective is to start a discussion about the real usefulness more or less sophisticated catalytic systems for Knoevenagel reaction with malononitrile, that can take place under mild conditions without need catalyst. From sustainable viewpoint questions are: Is it useful increase rate already occurs conditions? spend resources and time in designing, characterizing realizing complex such reaction? Does make sense carry out as have slower therefore find catalyst able it?